These Villains are the Cause of Skin Damage, Part 3

If we want to look at our anti-aging practices from an informed and discerning perspective, it’s good to know what’s going on in there that causes wrinkles (and other not-so-fun manifestations of skin aging). So far, we know about three main things that happen in the skin when damage is caused. Click HERE for the 1st Villain I wrote about, Click HERE for the 2nd in the series. Read on for the 3rd biochemical phenomenon in my series:

Advanced Glycation End-products (AGEs)
AGE is a a conveniently-coincidental acronym for Advanced Glycation End-products, which are the evil little products of a reaction between glucose (sugar) and proteins... Specifically collagen and elastin in this case (glycation).
Yes, it tastes good, but excess sugar in your diet screws up more than just your waistline.
How does it cause aging? 
Glucose is good, of course, in the way of providing energy. But when there's extra glucose, it rumbles with our collagen and elastin. This process produces AGEs, which make these fibers crispy and easily breakable. This reaction contributes to inflammation, slowed/inhibited growth of cells, and wrinkles (oh my!).
To simplify, think of it as turning your normal, elastic rubber band-like fibers into an old, dried out and crumbly rubber band. When AGE's wreak havoc, your rubber bands are in an accelerated aging state, causing that loss of elasticity, sagging, and wrinkles.
You know all those old, crumbly rubber bands in the back of your desk drawer? That's your elastin after AGE's.
In an article for Prevention, dermatologist Dr Frederic Brandt (well-known for his research in AGE's) breaks it down further: "Besides damaging collagen, a high-sugar diet also affects what type of collagen you have—another factor in how resistant skin is to wrinkling... The most abundant collagens in the skin are types I, II, and III, with type III being the most stable and longest lasting. Glycation transforms type III collagen into type I, which is more fragile.
The article goes on to describe that "AGEs deactivate your body's natural antioxidant enzymes, leaving you more vulnerable to sun damage—still the main cause of skin aging."
yikes! What Now?
1) It's time to build some new Collagen. If you're not already, start using a Retinol or Retinoid.
My favorites for sensitive or dry types:
My favorites for resistant or oily skin types:
Rx Tretinoin .05 or Tretinoin .1 creams
2) Diet:
Cut down on simple sugars in your diet. From a dietary perspective, refined sugar seems to impact glycation about 10 times more than glucose.
Yup, just another reason... Sorry.
Judgmental cat seems judgmental, but he really just cares about your complexion.
3) Use topical antioxidants.
These guys are ONCE AGAIN a great way to cut down on all the domino effects of damage. . Click HERE to read more about them. 
4) Try a Targeted Treatment Cream: One of my fave go-to's is Skinceuticals AGE Interrupter. Give it a Go if you're in the market for a rich, cosmetically-elegant treatment cream.
And Until Next time, Stay Fabulous My Friends!

These Villains are the cause of skin damage, Part 2

If we want to look at our anti-aging practices from an informed and discerning perspective, it's good to know what's going on in there that causes wrinkles (and other not-so-fun manifestations of skin aging). So far, we know about three main things that happen in the skin when damage is caused. Click HERE for the 1st Villain I wrote about. Here's the 2nd biochemical phenomenon in my series: •    The Villains: MMP's

MMPs: Don't let them get your collagen!! At theProductPro.com

Matrix Metalloproteinases (MMPs) are enzymes -envision Pac-Man!- activated by inflammation.  Inflammation can be caused by elements like UV exposure and infrared radiation. MMPs are not cool because they contribute to the breakdown of collagen. And as if that wasn't bad enough... they also work to inhibit new collagen formation.

For a scholarly article type of resource, check out this white paper on The National Center for Biotechnology Information website. They say Matrix-degrading metalloproteinases are key mediators of collagen degradation that is observed in photoaged skin. Key mediators? Oh man!! Screen Shot 2015-08-17 at 6.51.42 PM

Yikes! What to do now???

Don't freak out, its just one of the biochemical phenomena that results from CHRONIC damage and UV exposure. Let's be proactive about this...  Since we know MMPs are expressed as a result of UV and IR, we have a shot at preventing by using great SPF and using antioxidants. Click here to read more about some of my fave go-to antioxidants. And stay tuned for another edition of Skin Damage Villains, coming soon!

Antioxidant products at Theproductpro.com

Until Next Time, Stay Fabulous (and Informed!) my friends!

These Villains are damaging your skin: Part 1

If we want to look at our anti-aging practices from an informed and discerning perspective, it's good to know what's going on in there that causes wrinkles (and other not-so-fun manifestations of skin aging). So far, we know about three main things that happen in the skin when damage is caused...here's one:

The Production of Evil Villain #1: ROS, aka Reactive Oxygen Species

Free radicals: A bull in the china shop (of your skin) at theproductpro.wordpress.com

ROS: These little oxidative destructors are also known as free radicals. When they're produced by damage, they are missing an electron - so they'll tazmanian-devil through otherwise stable molecules wreaking all kinds of havoc.

Throughout this mission of destruction, they are looking to steal an electron for themselves, causing those other normal cells to become free-radicals, too. This chain reaction of destruction and theft leads to inflammation, damage, and the cross-linking of collagen and elastin (wrinkles!!)

Eeek! What should I do, you ask? The best product-related helpers are antioxidants and sunscreens, which both help prevent the formation in the first place, and help neutralize the offenders. (Picture a knight in shining armor, swinging a sword at an evil free radical... and read more about those here!)

Antioxidant products at Theproductpro.com

More on those villains later, and until next time, Stay Fabulous My Friends!

Neocutis to the Skin: 'I'm gonna need you to start the healing process, ok?'

I wanted to share a bit about my recent look into Neocutis Skin Care products, their technology,  and how their growth factor 'PSP' works. Here's the scoop.

Neocutis offers a number of products that feature technology that was developed by leading Swiss researchers out of the University Hospital of Lausanne, a leading international research facility. Their claim-to-fame/ proprietary ingredient is called PSP, which they have termed the "Cadillac of Peptides".

Here are some interesting facts about PSP and how it works:

The Healing Power of Peptides

Inspired by the phenomenon of the scarless healing of fetal skin, medical researchers in Switzerland created a biotechnology process to obtain the super power proteins involved in wound healing from cultured fibroblasts.  A dedicated cell bank was established for developing new wound healing and burn treatments with these amazing proteins.  That same cell bank is the source of the fibroblasts that produce PSP, which is Neocutis' secret weapon. By the way, fibroblasts are the collagen producing cell found in skin.

PSP

PSP stands for Processed Skin Proteins. PSP is a mixture of Human Growth Factors, interleukins, and the other cytokines that were discovered by those Swiss scientist smarty-pants.

Ok, so it heals wounds (that's pretty cool). But what does it do for the skin's appearance?

Let's face it: aging skin is damaged.  No matter what you want to primarily blame for the inflammation, damaged/aged skin is basically wounded skin.  The free-radical damage (reactive oxidative species) that causes the wound (aging/ skin damage) is caused by stuff like

  • glycation
  • injuries to the skin
  • pollution
  • chronic skin conditions
  • sun damage: the tanning bed you hit in high school, the baby oil/iodine days of the past, or even just daily daylight-exposure

The scientists found that even though the skin does not actually absorb the growth factors, they are proven to play what I like to think of as a game of 'telephone' with the skin when applied topically.  They are able to stimulate the healing process, actually acting to 'heal' the 'wound' of the aging/damaged skin.

Hey Skin, it's me, PSP. I'm gonna need you to start the healing process, STAT.The result is smoothed, brightened and firmed skin, all with no color or fragrance additives. Give it a try and see what you think! Check it out here: www.neocutis.com 

Until next time, stay fabulous, my friends!